Superman and Spider-Man - together again! Fifty years after their first, landmark team up, Mark Waid and Jorge Jiménez re-unite The Man of Steel and everyone's "Friendly Neighborhood Spider-Man" to face Doctor Octopus and Brainiac!

"Truth, Justice and Great Responsibility!"

NOTE: This issue features a plethora of variant covers.

Tom King and Jim Lee present Lois Lane & Mary Jane as "The World's Finest" (featuring a cameo by Gambit and a Sentinel!)

Superboy Prime and The Amazing Spider-Man in "Pages" (versus The High Evolutionary) by Christopher Priest and Daniel Sampere.

"Beyond the Cobwebs of Tomorrow" by Sean Gordon Murphy and Simon Gough teams Superboy and Spider-Man 2099 (featuring Batman Beyond!)

Superman's Pal, Jimmy Olsen meets Carnage in "Jimmy Con Carnage" by Matt Fraction and Steven Leiber.

Jeff Lemire and Rafa Sandoval present a tale of times past featuring Uncle Ben Parker and Jonathan Kent at "The Bridge" in Smallville.

The Crosshairs with Jack Ryder focuses on "Bias" in reporting between The Daily Planet and The Daily Bugle, with J. Jonah Jameson debating Lois Lane, by Greg Rucka and Nicola Scott.

Gail Simone and Belen Ortega present "Blind Date" with Power Girl and The Punisher facing a virtual Who's Who of super-villains!